2017-05-01

The CD47 gene is located on chromosome 3q13 and encodes an integrin-associated protein. CD47 is an important “self-labeling” molecule in the immunoglobulin superfamily that contains an immunoglobulin variable-like amino-terminal domain, five transmembrane …

CD47 is highly expressed on many different types of cancer, and it transduces inhibitory signals through SIRPα on … PDF | On Apr 1, 2017, Valerie R Wiersma and others published CD47, a multi-facetted target for cancer immunotherapy | Find, read and cite all the research you need on ResearchGate 2019-12-11 CD47 antibody retards the growth of spontaneous tumors. Medroxyprogesterone acetate (MPA) pellets (50 mg, 90-day release) were implanted subcutaneously into the interscapular area of However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor … A novel immunotherapy appears safe for use in patients with a type of blood cancer called non-Hodgkin’s lymphoma, according to a phase-1 multicenter clinical trial led by a researcher at the Stanford University School of Medicine.. Although some patients showed signs of a transitory anemia or reactions at the injection site, there were few other significant side effects to the treatment, the 2017-05-01 CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha (). CD-47 acts as a don't eat me signal to macrophages of the immune system The CD47 gene is located on chromosome 3q13 and encodes an integrin-associated protein.

Cd47 immunotherapy

1B). A binding competition assay confirmed the specificity of the interaction between KWAR23 and SIRPα on the surface of THP-1 cells, a human acute monocytic leukemia cell line that expresses SIRPα (Fig. 1C). The combination of CD47 blockade and macrophage activation by cabazitaxel synergizes to vastly enhance the elimination of TNBC cells. Our results show that targeting macrophages is a promising and effective strategy for TNBC treatment. Wiersma VR, van Bommel PE, de Bruyn M, et al.

Genom att utnyttja anti-CD47-antikroppsmedierad fagocytos av cancerceller av As such, NK cell-based immunotherapy holds a great promise for cancer

As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion.

CD47, a tumor cell surface marker, plays as “don't eat me signal” through binding its recept or SIRPα on macrophages and the antibody against CD47, which blocks interactions of CD47 with SIRPα, has been shown to lead to tumor destruction1.

Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who have cancer. Although cells of the myeloid lineage frequently infiltrate tumors and limit therapeutic success, currently approved immunotherapies primarily target tumor-infiltrating T and natural killer lymphocytes. The inhibitory receptor signal CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy.

Cell Death and Disease (2019) 10:36 Page 10 of 14 CD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using human and mouse TNBC preclinical models, we evaluated the efficacy of PrCR-based immunotherapy by blocking CD47. NIH investigators hope CD47 study leads to infectious diseases immunotherapy.

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The protein CD47 is expressed in high levels on the surface of many cancer cells, where it acts as a "don't eat me" signal to the immune system 's macrophages, commonly known as white blood cells.

Wiersma VR, van Bommel PE, de Bruyn M, et al. CD47, a multi-facetted target for cancer immunotherapy. Atlas of Genetics and Cytogenetics in Oncology and Haematology website. http 2018-12-11 · Monotherapy by CD47 blockade led to a reduction in tumor growth and an increase in overall survival. Of note, this treatment lead to a moderate depletion of M2 macrophages as well as close-to-complete elimination of regulatory T cells from the tumor bed, suggesting a strong favorable impact of CD47 blockade on the tumor microenvironment. The suppressive effect of macrophages was enhanced by blocking CD47 on pancreatic cancer cells, leading to decreased metastatic burden and prolonged survival.